Arsenal are staring at missing out on a place in the last 16 for the first time in more than 15 years after Arsene Wenger's men went down 3-2 to Olympiakos.
Having lost 2-1 to Dinamo Zagreb in the opening match of this season's Champions League, Arsenal absolutely needed a home victory against Olympiakos, a side which had never won in England prior to this match, but some horrible defending and defensive mistakes allowed the Greeks to come away with a big victory.
Felipe Padro opened the scoring for the away side, with his shot, off a corner, taking a big deflection to completely leave David Ospina stranded. Arsenal, though, equalised soon after as Theo Walcott ran onto a through ball from Alexis Sanchez before forcing the ball past Olympiakos goalkeeper Roberto.
However, Olympiakos would go into halftime with a 2-1 lead as a David Ospina howler have them the fillip needed to come out and produce a solid defensive display in the second half.
Arsenal, as expected, came out all guns blazing in the second 45, and after a concerted period of pressure, they finally broke through, when Alexis Sanchez headed a nice cross from Walcott.
However, a minute after that Arsenal goal, Olympiakos went a goal up again, this time for good, as Alfred Finnbogason flicked in a cross from Pardo.
Arsenal now have zero points from their first two games in Group F, and they somehow must defeat Bayern Munich in their next game to have any hopes of qualifying for the knockout stages of the Champions League. Easier said than done, considering the form Bayern Munich are in, with the Bundesliga champions thumping Dinamo Zagreb 5-0 in the other match in Group F.