Morgan Stanley plans to cut up to 25% of its fixed-income jobs, according to a person familiar with the matter.
The workforce reduction will be across all regions and is set to take place in the next two weeks, said the person.
The news was first reported by Bloomberg on Monday, 30 November.
The Wall Street bank reported a 42% slide in bond trading in the third quarter, one of its worst performances since the financial crisis.
Morgan Stanley Chief Executive James Gorman has been focusing on equities trading and particularly wealth management as profit-drivers for the No 6 US bank by assets as stricter regulations and capital requirements make it more difficult to trade bonds.
Ted Pick, who was in charge of the company's equities business, was picked by Gorman last month to oversee its entire trading business to facilitate better coordination between the firm's bond and equities desks.
Morgan Stanley declined to comment.
The company's shares, which have fallen 12.9% this year up to Friday's close, were up 2.1% in afternoon trading.